1. Fat-Loss & Metabolic Peptides
AOD-9604
- Mechanism: Mimics the fat-reducing domain of human growth hormone, promoting lipolysis and inhibiting fat formation.
- Research Insights: Studies show selective fat loss without activating full GH pathways; ideal for targeted adipose reduction.
- Pathways Activated: Lipolytic signaling, metabolic efficiency, nutrient partitioning.
5-Amino-1MQ
- Mechanism: Small-molecule NNMT inhibitor; increases NAD⁺ availability and accelerates cellular metabolism.
- Research Insights: Shown to enhance fat-loss in preclinical models via metabolic pathway upregulation.
- Pathways Activated: NNMT inhibition → increased NAD⁺ → mitochondrial efficiency → fat oxidation.
MOTS-c
- Mechanism: Mitochondrial-derived peptide; regulates AMPK and mitochondrial energy output.
- Research Insights: Acts as an exercise mimetic; boosts glucose uptake, fat oxidation, and metabolic flexibility.
- Pathways Activated: AMPK activation, mitochondrial biogenesis, glucose/fatty-acid utilization.
2. Muscle Growth & Recovery Peptides
IGF-1 LR3
- Mechanism: Long-acting IGF-1 analogue; binds IGF receptors to promote anabolic signaling.
- Research Insights: Enhances protein synthesis, cell proliferation, and tissue regeneration in models.
- Pathways Activated: IGF-1 receptor → AKT/mTOR → muscle hypertrophy.
CJC-1295 + Ipamorelin
- Mechanism: GH-releasing hormone + ghrelin receptor agonist; synergistically boosts pulsatile and sustained GH release.
- Research Insights: Increases recovery and lean tissue retention in preclinical studies.
- Pathways Activated: GH → IGF-1 axis → protein synthesis and fat oxidation.
BPC-157 + TB-500
- Mechanism: Angiogenic and regenerative peptides; BPC-157 promotes gut and soft tissue healing, TB-500 improves cellular migration and connective tissue repair.
- Research Insights: Widely studied for tendon, ligament, and muscle repair; reduces inflammation and promotes faster recovery.
- Pathways Activated: Angiogenesis, collagen remodeling, anti-inflammatory signaling.
3. Wellness & Longevity Peptides
GHK-Cu
- Mechanism: Copper peptide with regenerative properties; promotes collagen synthesis and tissue repair.
- Research Insights: Accelerates wound healing, improves skin/hair quality, and reduces cellular inflammation.
- Pathways Activated: ECM remodeling, anti-inflammatory, antioxidant gene expression.
NAD⁺
- Mechanism: Essential cofactor in redox reactions and sirtuin activation; regulates mitochondrial function and energy metabolism.
- Research Insights: Boosting NAD⁺ improves mitochondrial efficiency, DNA repair, and anti-aging pathways.
- Pathways Activated: Sirtuins, PARP, mitochondrial energy metabolism.
SLU-PP-332
- Mechanism: Small-molecule ERR agonist; mimics exercise effects on mitochondria.
- Research Insights: Shown to increase oxidative fibers, mitochondrial biogenesis, and endurance phenotypes in preclinical studies.
- Pathways Activated: ERR-mediated transcription → mitochondrial biogenesis → metabolic acceleration.
4. Multi-Pathway & Advanced Stacks
Retatrutide (GLP-3 / triple agonist)
- Mechanism: Targets GIP, GLP-1, and glucagon receptors; a triple-agonist for weight loss and metabolic enhancement.
- Research Insights: Potent reduction in body weight, improved glycemic control, and liver fat reduction in clinical trials.
- Pathways Activated: Incretin signaling, glucagon-mediated energy expenditure, appetite suppression.
KLOW
- Mechanism: Multi-peptide blend (BPC-157, TB-500, GHK-Cu, KPV) for tissue repair and anti-inflammatory support.
- Research Insights: Supports connective tissue regeneration and systemic recovery in preclinical research.
- Pathways Activated: Collagen synthesis, anti-inflammatory pathways, angiogenesis, tissue remodeling.
