Peptide Optimization & Synergy Guide

Optimal peptide combinations for maximum metabolic, regenerative, and performance outcomes. Each primary peptide is paired with its top three synergistic peptides to study combined effects on fat-loss, muscle growth, wellness, and overall health.

Top 3 Synergies: MOTS-c, NAD⁺, Retatrutide
Expected Research Results:

• Fat Loss: Accelerates lipolysis, inhibits fat formation, boosts metabolism.
   
• Muscle Growth: Supports lean tissue preservation during caloric restriction.
   
• Wellness/Recovery: Improves cellular energy efficiency and metabolic resilience.
   
• Overall Health: Enhances mitochondrial performance and energy homeostasis.
   

Top 3 Synergies: BPC-157, TB-500, KLOW
Expected Research Results:

• Fat Loss: Indirectly supports fat reduction by reducing inflammation.
   
• Muscle Growth: Promotes tissue repair and collagen synthesis for lean muscle support.
   
• Wellness/Recovery: Speeds wound healing, reduces inflammation, supports skin/hair health.
   
• Overall Health: Enhances regenerative processes and cellular vitality.
   

Top 3 Synergies: CJC-1295 + Ipamorelin, MOTS-c, NAD⁺
Expected Research Results:

• Fat Loss: Supports insulin sensitivity for better nutrient partitioning.
   
• Muscle Growth: Potent anabolic peptide — increases protein synthesis and hypertrophy.
   
• Wellness/Recovery: Accelerates post-injury recovery and tissue repair.
   
• Overall Health: Enhances systemic growth hormone/IGF axis efficiency.
   

Top 3 Synergies: IGF-1 LR3, MOTS-c, NAD⁺
Expected Research Results:

• Fat Loss: Boosts GH-mediated fat oxidation.
   
• Muscle Growth: Supports lean mass retention and hypertrophy.
   
• Wellness/Recovery: Improves sleep quality and recovery efficiency.
   
• Overall Health: Optimizes endocrine and metabolic health.
   

Top 3 Synergies: NAD⁺, SLU-PP-332, Retatrutide
Expected Research Results:

• Fat Loss: Enhances AMPK activation and fat oxidation.
   
• Muscle Growth: Protects lean tissue under caloric stress.
   
• Wellness/Recovery: Improves mitochondrial function, energy output, and endurance.
   
• Overall Health: Supports metabolic flexibility and anti-aging pathways.
   

Top 3 Synergies: CJC-1295 + Ipamorelin, NAD⁺, MOTS-c
Expected Research Results:

• Fat Loss: Reduces visceral and subcutaneous fat stores.
   
• Muscle Growth: Preserves lean mass during fat reduction.
   
• Wellness/Recovery: Supports metabolic and endocrine balance.
   
• Overall Health: Enhances GH-dependent metabolic processes and tissue health.
   

Top 3 Synergies: Ipamorelin, IGF-1 LR3, MOTS-c
Expected Research Results:

• Fat Loss: Supports GH-mediated fat metabolism.
   
• Muscle Growth: Increases anabolic signaling and protein synthesis.
   
• Wellness/Recovery: Improves cellular regeneration and tissue repair.
   
• Overall Health: Optimizes endocrine function and energy efficiency.
   

Top 3 Synergies: MOTS-c, Retatrutide, SLU-PP-332
Expected Research Results:

• Fat Loss: Enhances mitochondrial energy utilization and metabolic efficiency.
   
• Muscle Growth: Supports cellular energy supply for hypertrophy.
   
• Wellness/Recovery: Boosts DNA repair, anti-aging pathways, and recovery.
   
• Overall Health: Improves systemic metabolism, cardiovascular health, and longevity markers.
   

Top 3 Synergies: MOTS-c, NAD⁺, 5-Amino-1MQ
Expected Research Results:

• Fat Loss: Potent appetite suppression and energy expenditure increase.
   
• Muscle Growth: Supports lean tissue preservation under caloric deficit.
   
• Wellness/Recovery: Improves insulin sensitivity and liver function.
   
• Overall Health: Enhances overall metabolic health and anti-obesity outcomes.
   

Top 3 Synergies: GHK-Cu, KLOW, CJC-1295 + Ipamorelin
Expected Research Results:

• Fat Loss: Supports recovery from injury enabling continued activity.
   
• Muscle Growth: Accelerates tendon, ligament, and muscle repair for improved performance.
   
• Wellness/Recovery: Reduces inflammation and promotes tissue regeneration.
   
• Overall Health: Improves overall connective tissue health and injury resilience.
   

Top 3 Synergies: BPC-157, TB-500, GHK-Cu
Expected Research Results:

• Fat Loss: Indirectly supports metabolic activity by enhancing recovery and repair.
   
• Muscle Growth: Promotes soft tissue repair and collagen production.
   
• Wellness/Recovery: Speeds recovery from muscular or connective tissue strain.
   
• Overall Health: Enhances regenerative capacity across multiple tissue types.
   

Top 3 Synergies: MOTS-c, NAD⁺, Retatrutide
Expected Research Results:

• Fat Loss: Mimics exercise to increase metabolic rate and mitochondrial fat oxidation.
   
• Muscle Growth: Supports energy supply for lean tissue maintenance.
   
• Wellness/Recovery: Improves endurance markers and energy-system efficiency.
   
• Overall Health: Boosts metabolic health, mitochondrial biogenesis, and systemic resilience.
   

Top 3 Synergies: Retatrutide, MOTS-c, NAD⁺
Expected Research Results:

• Fat Loss: Accelerates fat-loss pathways via NNMT inhibition and NAD⁺ elevation.
   
• Muscle Growth: Preserves lean muscle during caloric deficit.
   
• Wellness/Recovery: Enhances cellular energy output and metabolic optimization.
   
• Overall Health: Supports systemic mitochondrial function and metabolic efficiency.